Setting up new practice and Software

Hi

I am looking at starting mu own practice and I am finding it difficult to decide on the best software. My queries are;

1. I am looking at cloud based systems as there seems to be a movement towards this, is this advisable?

2. Is it advisable to have various systems based on what clients are using? There is an obvious benefit to this but as I will likely have only a few clients I do not want to be buying lots of systems for cost reasons.

Thanks

David